Anastasia Antonacos has given notable performances around the world as a solo recitalist and chamber musician. She has played at venues such as the Salle Cortot, Casa Orfeo, Holland's Alkmaar Conservatory and Alice Tully Hall. She has also played in Greece, Russia, France and Belgium, as well as various places in the U.S., including Washington, D.C., where she testified for funding for the National Endowment for the Arts.

She won First Place at the International Young Artist Music Competition in Bulgaria, and she holds prizes from the Capdepera International Piano Competition in Mallorca and the Indianapolis Matinee Musicale Competition. In 2004, the Greek Women's University Club of Chicago awarded her the Kanellos Award. She attended the Holland Music Sessions, the Bowdoin Summer Music Festival and the Wilhelm Kempff Beethoven Course in Positano, Italy, where she was one of eight pianists selected for an intensive study of Beethoven led by John O'Conor.

Dr. Antonacos has made solo appearances with the Northshore Philharmonic Orchestra, the Midcoast Symphony Orchestra, the Portland Symphony Orchestra and the Bangor Symphony Orchestra. She has collaborated with violinist Joseph Silverstein, as well as with members of the Vermeer, Cassatt and DaPonte String Quartets. She was a chamber music coach at Bay Chamber Concerts' Next Generation program for many years. She regularly serves as a masterclass teacher and adjudicator. A former member of the full-time piano faculty at Indiana University of Pennsylvania, she holds a master's degree and doctorate in piano performance from Indiana University in Bloomington, and a bachelor's degree from the University of Southern Maine School of Music. She lives with her husband and daughter in Portland, where she was named one of the 100 Most Influential People of Portland by the Phoenix.